Molecular diversity and specializations among the cells of the adult mouse brain. Shared and distinct transcriptomic cell types across neocortical areas. Hierarchical organization of cortical and thalamic connectivity.
#Nature neuroscience driver
A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality. A mesoscale connectome of the mouse brain. The neocortical circuit: themes and variations.
Long distance projections of cortical pyramidal neurons. Thus, whole-brain single-neuron projectome analysis reveals organization principles of axon projections within and outside PFC and provides the essential basis for elucidating neuronal connectivity underlying diverse PFC functions. Finally, we showed that each transcriptome subtype corresponds to multiple projectome subtypes found in different PFC subregions. Furthermore, we obtained a high-precision hierarchical map within PFC and three distinct functionally related PFC modules, each enriched with internal recurrent connectivity. Further analysis unraveled topographic rules of soma distribution within PFC, first-order collateral branch point-dependent target selection and terminal arbor distribution-dependent target subdivision. Each of four previously known major cortico-cortical subnetworks was targeted by a distinct group of PFC subtypes defined by their first-order axon collaterals. Using single-neuron reconstruction of 6,357 mouse PFC projection neurons, we identified 64 projectome-defined subtypes. However, the whole-brain organization of PFC axon projections remains poorly understood. Prefrontal cortex (PFC) is the cognitive center that integrates and regulates global brain activity. Nature Neuroscience volume 25, pages 515–529 ( 2022) Cite this article Single-neuron projectome of mouse prefrontal cortex
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